“Splice” is a 2009 science fiction horror film directed by Vincenzo Natali. The movie stars Adrien Brody and Sarah Polley as geneticists who defy ethical boundaries by creating a new hybrid organism.

In the film, Clive (Adrien Brody) and Elsa (Sarah Polley) are brilliant scientists working on genetic experiments to create new species for medical purposes. Against their company’s directives, they decide to incorporate human DNA into their latest experiment, resulting in the creation of a new creature named Dren. Initially a success, Dren rapidly matures into a complex and dangerous being with unexpected capabilities and intelligence.

As Clive and Elsa struggle to keep their creation hidden from their employers and the world, tensions rise and ethical dilemmas intensify. Dren’s existence challenges the boundaries of science, ethics, and the definition of humanity itself, leading to unforeseen consequences that threaten everyone involved.

“Splice” received mixed reviews from critics for its provocative themes, unsettling atmosphere, and strong performances, particularly from Brody and Polley. The film explores complex themes such as bioethics, genetic manipulation, and the consequences of playing god. It remains a thought-provoking entry in the science fiction horror genre, offering a disturbing exploration of scientific ambition gone awry.